QR Cream is very different to all other pain creams

QR Cream is very different to all other pain creams

QR Cream’s unique formula delivers the clinically proven ingredient, Mannitol, deep into the affected areas, to provide fast acting, long lasting relief of aching, burning or tingling pain

QR Cream is the first and only commercially available pain cream to contain the active ingredient, Mannitol.

QR Cream’s unique formula delivers the clinically proven ingredient, Mannitol, deep into the affected areas, to provide fast acting, long lasting relief of aching, burning or tingling pain.

The human body is made up of trillions of cells. The cells of the nervous system are called nerve cells. The axons of nerve cells are like wires that carry messages in the form of electrical signals to the brain. Your brain is where you feel the sensations. For example, when your toe is injured, the nerves supplying your toe will send an electric pain signal to your brain. When your brain receives that signal, you feel pain.


This is how the signal is generated in your nerve cells: Like all cells, nerve cells are full of potassium (K+), an alkali metal. Sodium (Na+) and calcium (Ca++) are also alkali metals and they surround the nerve cells. The + after their name means that they have a positive electrical charge. The walls of nerve cells have little pumps that pump potassium in and pump sodium and calcium out. These pumps make sure the cell contains the right chemicals and their electric charge is always the same.

We know that hot pepper, capsaicin, opens the pain channel, allowing sodium (Na+) and calcium (Ca++) into the nerve cell, which is why it is so quick to cause a burning sensation when applied to the skin or the tongue. We tested 25 people by putting a hot pepper (capsaicin) cream on their upper lip. When the burning sensation reached 8/10, on one side of the upper lip we applied the base cream and on the other side we applied the base cream with mannitol. Then, for 10 minutes, every minute we asked them how bad the burning was from 0 to 10 on each side of their upper lip. On the mannitol side, the burning went down very quickly, which did not happen on the base cream alone side. After 3 minutes, there was only a 2% chance that the 2 creams were the same and at 10 minutes, there was less than 1 in 1000 chance that the 2 creams were the same. On the mannitol side the burning was gone but it persisted on the base cream alone side.


That told us that mannitol quickly blocks the pain messages coming from the channel that responds to hot pepper, the body’s main pain channel. How it does it and why it works faster and better than local anesthetics is not yet known. Local anaesthetics also block all the sodium (Na+) channels, so they take away all feeling: they make you numb. In contrast, mannitol only stops the pain signal. You are still able to feel other sensations when you use Mannitol.